Lack of efficacy of the standard potency Edmonston-Zagreb live, attenuated measles vaccine in African infants.
نویسندگان
چکیده
The efficacy of standard potency Edmonston-Zagreb (E-Z) measles vaccine was tested in a randomized trial of Black infants in a rural area of South Africa where a measles epidemic was occurring. The following immunization schedules were used: 48 infants aged 4-8.5 months who received 3.9 log 50 infectious units of E-Z vaccine (group A); 48 infants aged 4-8.5 months who received 3.28 log 50 infectious units of Schwarz vaccine (group B); and 28 infants aged greater than 9 months who received 3.28 log 50 infectious units of Schwarz vaccine and served as controls (group C). For infants aged less than 23 weeks who were given either the E-Z or Schwarz vaccine, the number of seropositives was low (28%), irrespective of the pre-vaccination level of measles antibody. There was a higher number of seropositives (68%) among those in the age range greater than 23 weeks to less than 36 weeks who received the E-Z vaccine rather than the Schwarz vaccine (36%). When administered to children aged greater than 36 weeks, the Schwarz vaccine produced a satisfactory, though suboptimal response rate (61%). There was no correlation between seropositivity and pre-vaccination measles antibody status. Use of the standard dose of E-Z vaccine may have been one of the factors for this poor response, and this supports the WHO recommendation that titres higher than the standard potency vaccine are needed if 6-month-old infants are to be successfully immunized against measles.
منابع مشابه
Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial
OBJECTIVE To examine the protective efficacy of measles vaccination in infants in a low income country before 9 months of age. DESIGN Randomised clinical trial. PARTICIPANTS 1333 infants aged 4.5 months: 441 in treatment group and 892 in control group. SETTING Urban area in Guinea-Bissau. INTERVENTION Measles vaccination using standard titre Edmonston-Zagreb vaccine at 4.5 months of age...
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عنوان ژورنال:
- Bulletin of the World Health Organization
دوره 69 2 شماره
صفحات -
تاریخ انتشار 1991